pertussis toxin-insensitive ccr5 signaling in macrophage
| PAG Title | pertussis toxin-insensitive ccr5 signaling in macrophage |
| PAG ID | WAG000227 |
| Type | P |
| Source Link |  BioCarta |
| Publication Reference | NA |
| PAG Description | The chemokine receptors CCR5 and CXCR4 in macrophages are activated by their peptide ligands and also by the HIV envelope protein GP120 during HIV infection. One mechanism of sigling by these GPCRs is through activation of Gi sigling. These chemokine receptors can also sigl through a Gi-independent pertussis toxin-insensitive pathway. This pathway elevates calcium influx into the cell through CRAC channels, ion channels that are activated by calcium release. Elevated calcium from CRAC is required for downstream activation of Pyk2, a focal adhesion-associated protein kise. Non Gi sigling by these chemokine receptors also involves the Jnk and p38 Map kise pathways leading to AP-1 activation and activation of genes such as MIP-1 and MCP-1. This pathway may be involved in the role of macrophages in the pathogenesis of AIDS. |
| Species | Homo sapiens |
| nCoCo Score | 1,295 |
| Base PAG ID | WAG000227 |
| Human Phenotyte Annotation | |
| Curator | PAGER curation team |
| Curator Contact | PAGER-contact@googlegroups.com |
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